• Intracortical MPH improved cortical cell excitability in rats, an result that was lost next catecholamine depletion and was mediated by using stimulation of ?two adrenergic receptors but not D1 receptors• AMP Increased the cellular response of cortical and hippocampal neurons to CHPG (an mGluR sort five agonist) in rats• MPH lowered oxy-hem